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Because of the significant accumulation of clinical evidence[1] S. boulardii is recommended by the ESPGHAN2 for the treatment of all type of acute diarrhea in children in addition to ORS (refer to the package insert for the mode of administration).

1. Szajewska et Al, ALIMENT PHARMACOL THER, 2007, 25 (3), 257–264
2. Guarino et Al, J PEDIATR GASTROENTEROL NUTR. 2008 May;46(5):619-21

Yes, but consult the package insert. S. boulardii's efficacy has been demonstrated in the prevention of diarrhea:

  • prevention of antibiotic-associated diarrhea in adults and children,[1][2]
  • prevention in travelers' diarrhea in adults,[3] and
  • prevention of recurrent Clostridium difficile disease in adults.[4]

In addition, it has been demonstrated in Billoo's study that treating children suffering from acute diarrhea with S. boulardii and ORS reduces the rate of relapse.[5]

Consult the package insert. To date, there are encouraging results from pilot studies[1][2] however, there is currently no clinical evidence demonstrated in clinical trials with S. boulardii specifically in patients suffering from IBS-C (IBS constipation).

1. Maupas et Al, MEDECINE ET CHIRURGIE DIGESTIVES 1983; 12(1):77-79
2. Swidsinski & al. GASTROENTEROLOGY 2008 Aug;135(2):568-79.

To date, S. boulardii is not indicated in Inflammatory Bowel Disease. Nevertheless, pilot trials demonstrate encouraging results.[1][2]

1. Guslandi et Al, DIGESTIVE DISEASES AND SCIENCES 2000 Jul; 45(7):1462-4
2. Guslandi et Al, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 2003 Jun; 15(6):697-8

To date, S. boulardii is not indicated in the treatment of Helicobacter pylori. Nevertheless, pilot trials demonstrate encouraging results in the treatment of Helicobacter pylori with S. boulardii in children as well as adults.[1][2][3][4]

1. Cindoruk et Al, HELICOBACTER 2007Aug; 12(4):309-16
2. Hurduc et Al, ACTA PEDIATRICA 2009 Jan; 98(1):127-31
3. Gotteland et Al, ACTA PAEDIATRICA, 2005 Dec; 94(12):1747-51
4. Song MJ, et Al Helicobacter. 2010 Jun;15(3):206-13.

No, S. boulardii is not a substitute for ORS (Oral Rehydration Solution). S.boulardii has to be prescribed in association with ORS as demonstrated in clinical trials.[1]

1. Szajewska et Al, ALIMENT PHARMACOL THER , 2007, 25 (3), 257–264