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If not otherwise mentioned in the package insert, you can prescribe S. boulardii in lactose-intolerant patients. S. boulardii capsules and sachets contain 32.5 mg of lactose/250 mg dose. It has been clinically demonstrated that drugs containing 400 mg of lactose or less can be prescribed safely.[1]

No, a few very rare cases of patients suffering from fungemia have been reported. All these patients were wearing a central venous catheter.[1] Therefore, the prescription is contra-indicated and because the contamination is probably of exogenic origin, special caution is advised if Saccharomyces boulardii is handled near these patients.

1. Hennequin C, EUR J CLIN MICROBIOL INFECT DIS (2000) 19:16-20

No, to date, there is no evidence of S. boulardii efficacy in pregnant women.

Yes, with caution. S. boulardii is not excreted in breast milk.

If not otherwise mentioned in the package insert, diabetics should take into account that S. boulardii capsules contain less than 100mg of sucrose per 50 mg. S. boulardii sachets contain fructose, and therefore, can be administered to diabetic patients.

S. boulardii should be prescribed for the prevention of antibiotic-associated diarrhea in children due to the risk of diarrhea. In addition you may prescribe S. boulardii in:

  • patients taking a broad spectrum of antibiotics[1],
  • patients with a history of antibiotic-associated diarrhea[1], and
  • patients with a long-term hospital stay[1].

1. Szajewska et Al, ALIMENT PHARMACOL THERAP, 2005;22:365-372

Yes, S. boulardii's efficacy has been demonstrated in adults for:

  • prevention of antibiotic-associated diarrhea[1],
  • prevention of travelers' diarrhea[1],
  • prevention of recurrent Clostridium difficile disease[1], and
  • treatment of acute diarrhea[1].

Prescribe S. boulardii following the dose listed in the package insert.

1. McFarland LV. World J Gastroenterol. 2010 May 14;16(18):2202-22